NANOTECNOLOGIA: REVISÃO INTEGRATIVA SOBRE USO DE NANOEMULGÉIS EM COSMECÊUTICOS
DOI:
https://doi.org/10.24933/rep.v7i1.291Palavras-chave:
Nanotecnologia, nanoemulgéis, nanoemulsões, cosmecêuticos.Resumo
Com o avanço tecnológico nos dias atuais e o desejo da aparência perfeita, as buscas por tecnologias que podem favorecer a qualidade e os resultados obtidos por produtos cosméticos, no mercado da estética e beleza, vem crescendo cada vez mais. A nanotecnologia é uma área da ciência responsável pelos estudos e produção de sistemas estruturados em escalas nanométricas. Em sua forma nano, materiais tendem a mudar suas propriedades e dessa forma, é possível a criação ou aperfeiçoamento de determinados produtos, dentre eles os cosméticos, reunindo benefícios como controle de liberação, maior permeação cutânea, estabilidade e direcionamento de moléculas para o local de ação. Esse trabalho consiste em uma revisão integrativa sobre inovações nanotecnológicas aplicadas em cosmecêuticos, focando no potencial uso de nanoemulgéis para produtos destinados à pele, seus métodos de preparo, caracterização, desafios de formulação, usos, vantagens e possíveis riscos. Foi realizado um levantamento de dados em bases eletrônicas, considerando os critérios de inclusão, exclusão e seleção de artigos para discussão. Os trabalhos selecionados relatam aspectos promissores sobre o uso tópico de nanoemulgéis, mas, também evidenciam questões importantes e que requerem maior atenção, como a necessidade de regulação do setor, ampliação dos estudos de segurança, qualidade e eficácia.
Downloads
Referências
ABIHPEC. Associação Brasileira da Indústria de Higiene Pessoal, Perfumaria e Cosméticos, 2021. Disponível em: <https://abihpec.org.br/comunicado/setor-de-higiene-pessoal-perfumaria-e-cosmeticos-fecha-2020-com-crescimento-de-58/>. Acesso em 12 de maio de 2023.
AITHAL, G. C. et al. Localized in situ nanoemulgel drug delivery system of quercetin for periodontitis: development and computational simulations. Molecules, v. 23, n. 6, p. 1363, 2018. DOI: https://doi.org/10.3390/molecules23061363
ALAM, A. et al. Babchi Oil-Based Nanoemulsion Hydrogel for the Management of Psoriasis: A Novel Energy Economic Approach Employing Biosurfactants. Gels, v. 8, n. 12, p. 761, 2022. DOI: https://doi.org/10.3390/gels8120761
ALGAHTANI, M. S. et al. Co-delivery of imiquimod and curcumin by nanoemugel for improved topical delivery and reduced psoriasis-like skin lesions. Biomolecules, v. 10, n. 7, p. 968, 2020. DOI: https://doi.org/10.3390/biom10070968
ALGAHTANI, M. S. et al. Thymoquinone loaded topical nanoemulgel for wound healing: formulation design and in-vivo evaluation. Molecules, v. 26, n. 13, p. 3863, 2021. DOI: https://doi.org/10.3390/molecules26133863
ALGAHTANI, M. S.; AHMAD, M. Z.; AHMAD, J. Nanoemulgel for improved topical delivery of retinyl palmitate: formulation design and stability evaluation. Nanomaterials, v. 10, n. 5, p. 848, 2020. DOI: https://doi.org/10.3390/nano10050848
ALHAKAMY, N. A. et al. Development, optimization, and evaluation of luliconazole nanoemulgel for the treatment of fungal infection. Journal of Chemistry, v. 2021, p. 1-13, 2021. DOI: https://doi.org/10.1155/2021/4942659
ALMOSTAFA, M. M. et al. Novel formulation of fusidic acid incorporated into a myrrh-oil-based nanoemulgel for the enhancement of skin bacterial infection treatment. Gels, v. 8, n. 4, p. 245, 2022. DOI: https://doi.org/10.3390/gels8040245
ALYOUSSEF, A. et al. The beneficial activity of curcumin and resveratrol loaded in nanoemulgel for healing of burn-induced wounds. Journal of Drug Delivery Science and Technology, v. 62, p. 102360, 2021. DOI: https://doi.org/10.1016/j.jddst.2021.102360
AMAN, R. M.; ABU HASHIM, I. I.; MESHALI, M. M. Novel Clove essential oil nanoemulgel tailored by Taguchi’s model and scaffold-based nanofibers: Phytopharmaceuticals with promising potential as cyclooxygenase-2 inhibitors in external inflammation. International Journal of Nanomedicine, p. 2171-2195, 2020. DOI: https://doi.org/10.2147/IJN.S246601
ARIANTO, A. et al. Preparation and evaluation of nanoemulgels containing a combination of grape seed oil and anisotriazine as sunscreen. Open Access Macedonian Journal of Medical Sciences, v. 8, n. B, p. 994-999, 2020. DOI: https://doi.org/10.3889/oamjms.2020.5293
ASFOUR, H. Z. et al. Design of Experiment Navigated Methodical Development of Neem Oil Nanoemulsion Containing Tea Tree Oil for Dual Effect Against Dermal Illness: Ex Vivo Dermatokinetic and In Vivo. Journal of Cluster Science, v. 34, n. 3, p. 1311-1323, 2023. DOI: https://doi.org/10.1007/s10876-022-02301-x
ASHAOLU, T.J. Nanoemulsions for health, food, and cosmetics: a review. Environmental Chemistry Letters, v. 19, n. 4, p. 3381-3395, 2021. DOI: https://doi.org/10.1007/s10311-021-01216-9
ASTUTI, K. et al. Anti-inflammatory activity of mangosteen (Garcinia Mangostana Linn.) rind extract nanoemulgel and gel dosage forms. Biomedical and Pharmacology Journal, v. 12, n. 04, p. 1767-1774, 2019. DOI: https://doi.org/10.13005/bpj/1807
BRASIL. Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Resolução RDC nº 7, de 1º de fevereiro de 2015. Dispõe sobre os requisitos técnicos para a regularização de produtos de higiene pessoal, cosméticos e dá outras providências. Brasília: Ministério da Saúde, 2015.
BRASIL. Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Resolução da Diretoria Colegiada. Portaria nº 1.358, de 20 de agosto de 2014, institui o Comitê Interno de Nanotecnologia da Agência Nacional de Vigilância Sanitária - ANVISA e dá outras providências. Brasília: Ministério da Saúde, 2014.
CERQUEIRA, C. et al. Nanovesicle-based formulations for photoprotection: a safety and efficacy approach. Nanotechnology, v. 30, n. 34, p. 345102, 2019. DOI: https://doi.org/10.1088/1361-6528/ab177c
CHE MARZUKI, N. H.; WAHAB, R. A.; ABDUL HAMID, M. An overview of nanoemulsion: concepts of development and cosmeceutical applications. Biotechnology & biotechnological equipment, v. 33, n. 1, p. 779-797, 2019. DOI: https://doi.org/10.1080/13102818.2019.1620124
CHITKARA, A. et al. Design-of-Experiments (DoE)-Assisted Fabrication of Quercetin-Loaded Nanoemulgel and Its Evaluation against Human Skin Cancer Cell Lines. Pharmaceutics, v. 14, n. 11, p. 2517, 2022. DOI: https://doi.org/10.3390/pharmaceutics14112517
CORREA, L. et al. In vitro protective effect of topical nanoemulgels containing Brazilian red propolis benzophenones against UV-induced skin damage. Photochemical & Photobiological Sciences, v. 19, p. 1460-1469, 2020. DOI: https://doi.org/10.1039/d0pp00243g
DONTHI, Mahipal Reddy et al. Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery. Pharmaceutics, v. 15, n. 1, p. 164, 2023. DOI: https://doi.org/10.3390/pharmaceutics15010164
DRAELOS, Z. D. Cosmeceuticals: What’s real, what’s not. Dermatologic Clinics, v. 37, n. 1, p. 107-115, 2019. DOI: https://doi.org/10.1016/j.det.2018.07.001
EID, A. M. et al. Antibacterial activity of Fusidic acid and sodium Fusidate nanoparticles incorporated in pine oil Nanoemulgel. International Journal of Nanomedicine, p. 9411-9421, 2019. DOI: https://doi.org/10.2147/IJN.S229557
EID, A. M. et al. Antibacterial and Anti-Acne Activity of Benzoyl Peroxide Nanoparticles Incorporated in Lemongrass Oil Nanoemulgel. Gels, v. 9, n. 3, p. 186, 2023. DOI: https://doi.org/10.3390/gels9030186
EID, A. M. et al. Evaluation of anticancer, antimicrobial, and antioxidant activities of rosemary (Rosmarinus Officinalis) essential oil and its Nanoemulgel. European Journal of Integrative Medicine, v. 55, p. 102175, 2022. DOI: https://doi.org/10.1016/j.eujim.2022.102175
ESMAEILI, F. et al. Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: An in vivo study. BMC Complementary Medicine and Therapies, v. 22, n. 1, p. 1-10, 2022. DOI: https://doi.org/10.1186/s12906-022-03619-9
FATIMA, M. et al. In silico drug screening based development of novel formulations for onychomycosis management. Gels, v. 7, n. 4, p. 221, 2021. DOI: https://doi.org/10.3390/gels7040221
FERNANDO, W. T.; NERANJA, A. G. K.; KANKANAMGE, S.U. A review on various plant-derived nanoemulgels and their applications. World Journal of Advanced Research and Reviews, v. 15, n. 3, p. 214-221, 2022. DOI: https://doi.org/10.30574/wjarr.2022.15.3.0916
FERREIRA, H. S.; RANGEL, M.C. Nanotecnologia: aspectos gerais e potencial de aplicação em catálise. Química nova, v. 32, p. 1860-1870, 2009. DOI: https://doi.org/10.1590/S0100-40422009000700033
FYTIANOS, G.; RAHDAR, A.; KYZAS, G. Z. Nanomaterials in cosmetics: Recent updates. Nanomaterials, v. 10, n. 5, p. 979, 2020. DOI: https://doi.org/10.3390/nano10050979
GURPREET, K.; SINGH, S. K. Review of nanoemulsion formulation and characterization techniques. Indian Journal of Pharmaceutical Sciences, v. 80, n. 5, p. 781-789, 2018. DOI: https://doi.org/10.4172/pharmaceutical-sciences.1000422
HOSNY, K. M. et al. Development and optimization of cinnamon oil nanoemulgel for enhancement of solubility and evaluation of antibacterial, antifungal and analgesic effects against oral microbiota. Pharmaceutics, v. 13, n. 7, p. 1008, 2021. DOI: https://doi.org/10.3390/pharmaceutics13071008
INDRAYANI, A. W. et al. The potential of sunscreen preparation containing ethanol extract of Moringa oliefera leaves in nanoemulgel formulation. Bali Medical Journal, v. 9, n. 3, p. 893-903, 2020. DOI: https://doi.org/10.15562/bmj.v9i3.2081
JUNQUEIRA, J. S. S.; SILVA, P.P.; GUERRA, W. Ouro. Química Nova na Escola, Brasil, v. 34, p. 45-46, 2012.
KAUL, S. et al. Role of nanotechnology in cosmeceuticals: a review of recent advances. Journal of pharmaceutics, v. 2018, 2018. DOI: https://doi.org/10.1155/2018/3420204
KHATOON, K. et al. Novel nanoemulsion gel containing triple natural bio-actives combination of curcumin, thymoquinone, and resveratrol improves psoriasis therapy: In vitro and in vivo studies. Drug delivery and translational research, v. 11, p. 1245-1260, 2021. DOI: https://doi.org/10.1007/s13346-020-00852-y
LAL, D.K. et al. An Overview of Nanoemulgels for Bioavailability Enhancement in Inflammatory Conditions via Topical Delivery. Pharmaceutics, v. 15, n. 4, p. 1187, 2023. DOI: https://doi.org/10.3390/pharmaceutics15041187
LEWIŃSKA, A. Optimizing the process design of oil-in-water nanoemulsion for delivering poorly soluble cannabidiol oil. Processes, v. 9, n. 7, p. 1180, 2021. DOI: https://doi.org/10.3390/pr9071180
MARCONE, G. P. S. Nanotecnologia e nanociência: aspectos gerais, aplicações e perspectivas no contexto do Brasil. Revista Eletrônica Perspectivas da Ciência e Tecnologia-ISSN: 1984-5693, v. 7, n. 2, p. 1-1, 2015.
MIASTKOWSKA, M.; KULAWIK-PIÓRO, A.; SZCZUREK, M. Nanoemulsion gel formulation optimization for burn wounds: Analysis of rheological and sensory properties. Processes, v. 8, n. 11, p. 1416, 2020. DOI: https://doi.org/10.3390/pr8111416
OJHA, B. et al. Nanoemulgel: a promising novel formulation for treatment of skin ailments. Polymer Bulletin, v. 79, n. 7, p. 4441-4465, 2022. DOI: https://doi.org/10.1007/s00289-021-03729-3
RAI, V. K. et al. Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: Formulation development, stability issues, basic considerations and applications. Journal of controlled release, v. 270, p. 203-225, 2018. DOI: https://doi.org/10.1016/j.jconrel.2017.11.049
REHMAN, A. et al. Fabrication, in vitro, and in vivo assessment of eucalyptol-loaded nanoemulgel as a novel paradigm for wound healing. Pharmaceutics, v. 14, n. 9, p. 1971, 2022. DOI: https://doi.org/10.3390/pharmaceutics14091971
SALEM, M. A. et al. Coriander (Coriandrum sativum L.) essential oil and oil-loaded nano-formulations as an anti-aging potentiality via TGFβ/SMAD pathway. Scientific reports, v. 12, n. 1, p. 6578, 2022. DOI: https://doi.org/10.1038/s41598-022-10494-4
SEVERINO, P. et al. Elastic liposomes containing benzophenone-3 for sun protection factor enhancement. Pharmaceutical Development and Technology, v. 17, n. 6, p. 661-665, 2012. DOI: https://doi.org/10.3109/10837450.2011.580762
SHAWAHNA, R. Effects of a grapeseed oil (Vitis vinifera L.) loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin: A split‐face, blinded, placebo‐controlled study. Journal of Cosmetic Dermatology, v. 21, n. 11, p. 5730-5738, 2022. DOI: https://doi.org/10.1111/jocd.15161
SIDDIQUI, A. et al. Investigation of a Minocycline-Loaded Nanoemulgel for the Treatment of Acne Rosacea. Pharmaceutics, v. 14, n. 11, p. 2322, 2022. DOI: https://doi.org/10.3390/pharmaceutics14112322
SINDI, A. M. et al. Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis. Drug Delivery, v. 30, n. 1, p. 2173337, 2023. DOI: https://doi.org/10.1080/10717544.2023.2173337
SINDI, A.M. et al. Utilization of experimental design in the formulation and optimization of hyaluronic acid–based nanoemulgel loaded with a turmeric–curry leaf oil nanoemulsion for gingivitis. Drug Delivery, v. 30, n. 1, p. 2184311, 2023. DOI: https://doi.org/10.1080/10717544.2023.2184311
SOLIMAN, M. et al. Contrasting the efficacy of pulsed dye laser and photodynamic methylene blue nanoemulgel therapy in treating acne vulgaris. Archives of Dermatological Research, v. 313, p. 173-180, 2021. DOI: https://doi.org/10.1007/s00403-020-02093-y
SOUZA, M.T.; SILVA, M. D.; CARVALHO, R. Revisão integrativa: o que é e como fazer. Einstein (São Paulo), v. 8, p. 102-106, 2010. DOI: https://doi.org/10.1590/s1679-45082010rw1134
SULTAN, M. H. et al. Development and optimization of methylcellulose-based nanoemulgel loaded with Nigella sativa oil for oral health management: Quadratic model approach. Molecules, v. 27, n. 6, p. 1796, 2022. DOI: https://doi.org/10.3390/molecules27061796
SULTANA, N. et al. Nanoemulgel: For Promising Topical and Systemic Delivery. 2022. DOI: https://doi.org/10.5772/intechopen.103878
SUNGPUD, C. et al. Techno-biofunctionality of mangostin extract-loaded virgin coconut oil nanoemulsion and nanoemulgel. Plos one, v. 15, n. 1, p. e0227979, 2020. DOI: https://doi.org/10.1371/journal.pone.0227979
TAHA, M. et al. Nanogels as Potential Delivery Vehicles in Improving the Therapeutic Efficacy of Phytopharmaceuticals. Polymers, v. 14, n. 19, p. 4141, 2022. DOI: https://doi.org/10.3390/polym14194141
TAYAH, D. Y.; EID, Ahmad M. Development of miconazole nitrate nanoparticles loaded in nanoemulgel to improve its antifungal activity. Saudi Pharmaceutical Journal, v. 31, n. 4, p. 526-534, 2023. DOI: https://doi.org/10.1016/j.jsps.2023.02.005
TING, T. C. et al. Development and Characterization of Nanoemulgel Containing Piper betle Essential Oil as Active Ingredient. In: IOP Conference Series: Earth and Environmental Science. IOP Publishing, 2020. p. 012032. DOI: https://doi.org/10.1088/1755-1315/596/1/012032
ULLAH, N. et al. Development and Evaluation of Essential Oil-Based Nanoemulgel Formulation for the Treatment of Oral Bacterial Infections. Gels, v. 9, n. 3, p. 252, 2023. DOI: https://doi.org/10.3390/gels9030252
WEIMER, P. et al. Correlation between the Skin Permeation Profile of the Synthetic Sesquiterpene Compounds, Beta-Caryophyllene and Caryophyllene Oxide, and the Antiedematogenic Activity by Topical Application of Nanoemulgels. Biomolecules, v. 12, n. 8, p. 1102, 2022. DOI: https://doi.org/10.3390/biom12081102
WILSON, R. J. et al. Nanoemulsions for drug delivery. Particuology, v. 64, p. 85-97, 2022. DOI: https://doi.org/10.1016/j.partic.2021.05.009
YADWADE, R.; GHARPURE, S.; ANKAMWAR, B. Nanotechnology in cosmetics pros and cons. Nano Express, v. 2, n. 2, p. 022003, 2021. DOI: https://doi.org/10.1088/2632-959X/abf46b
ZHOU, Y. Research Progress in Preparation, Stability and Application of Nanoemulsion. Journal of Physics: Conference Series, v. 2152, n. 1, p. 012044, 2022. DOI: https://doi.org/10.1088/1742-6596/2152/1/012044
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2023 teste
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
a) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
b) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
c) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado (Veja O Efeito do Acesso Livre).
